A complete English translation of the correspondence between the philosopher Martin Heidegger and the novelist and essayist Ernst Jünger, together with a translation of Jünger’s essay Across the Line.

In eukaryotic cells terminally misfolded proteins of the secretory pathway are retarded in the endoplasmic reticulum (ER) and subsequently degraded in a ubiquitin‐proteasome‐dependent manner. This highly conserved process termed ER‐associated protein degradation (ERAD) ensures homeostasis in the secretory pathway by disposing faulty polypeptides and preventing their deleterious accumulation and eventual aggregation in the cell. The focus of this paper is the functional description of membrane‐bound ubiquitin ligases, which are involved in all critical steps of ERAD. In the end we want (...) to speculate on how the modular architecture of these entities ensures the specificity of substrate selection and possibly accomplishes the transport of misfolded polypeptides from the ER into the cytoplasm. (shrink)

Die Autoren berichten über die erste kontrollierte Psychotherapiestudie, die psychoanalytische und kognitiv-verhaltenstherapeutische Langzeitpsychotherapien mit randomisierter und präferierter Zuweisung mit­einander vergleicht. In vier Behandlungszentren wurden 554 chronisch depressive Patienten interviewt, von denen 252 in die Studie aufgenommen werden konnten. In den Selbsteinschätzungen der Patienten zeigten sich große und stabile Veränderungen. Die vollständige Remissionsrate (für BDI) lag nach einem Jahr bei 34 % und stieg auf 45 % nach drei Jahren. Analoge Ergebnisse zeigten sich in den Einschätzungen der unabhängigen, bezogen auf die (...) Therapieverfahren verblindeten Rater (QIDS). Entgegen ihrer Hypothesen fanden die Autoren aber keinen statistisch signifikanten Unterschied zwischen den Verfahren und auch keine Effektunterschiede zwischen randomisierter Therapiezuweisung und Behandlung mit der präferierten Psychotherapie. Besser als in anderen Studien sind die erzielten Remissionsraten, die zeigten, dass chronisch depressive Patienten von Langzeitpsychotherapien profitieren. (shrink)

Evolutionary change is opportunistic, but its course is strongly constrained in several fundamental ways. These constraints (historical/phylogenetic, functional/adaptive, constructional/morphogenetic) and their dynamic relationships are discussed here and shown to constitute the conceptual framework of Constructional Morphology. Notwithstanding recent published opinions which claim that the discovery of constraints renders Neodarwinian selection theory obsolete, we regard the insights of Constructional Morphology as being entirely consistent with this theory. As is shown here in the case of the Hyracoidea, formal analysis of the constraints (...) which have framed the evolution of various characters extends our understanding of the evolution of a taxon. (shrink)

Almost two decades ago, Prahalad and Hammond [Harv Bus Rev, 80(9):48–59, 2002] introduced the base/bottom of the pyramid (BOP) approach to profitably serving the poor with business models adapted from developed markets while alleviating poverty. In response to disappointing results and ethical criticism, the BOP approach evolved from a just-for-profit approach with a passive role of the poor to an inclusive development approach that integrates the principles of the triple bottom line. A recent review of the BOP literature [Dembek et (...) al., J Bus Ethics 165(3):365–382, 2020], however, reveals a lack of empirical evidence to support the sustainable BOP approach. In this paper, we specify the assumptions underlying the sustainable BOP approach and test them using structural equation modeling with clustered robust standard errors on a unique dataset of 212 firms. Our findings show that BOP business model involvement and adaptive capacity are significant drivers of the triple bottom line at the BOP; however, business model adaptive capacity does not guarantee an ecologically sustainable performance at the BOP. We find that there is a need for further extension of the ethical foundations of the sustainable BOP approach. (shrink)

Ernst Cassirer occupies a unique space in Twentieth-century philosophy. A great liberal humanist, his multi-faceted work spans the history of philosophy, the philosophy of science, intellectual history, aesthetics, epistemology, the study of language and myth, and more. Cassirer's thought also anticipates the renewed interest in the origins of analytic and continental philosophy in the Twentieth Century and the divergent paths taken by the 'logicist' and existential traditions, epitomised by his now legendary debate in 1929 with the philosopher Martin (...) Heidegger, over the question "What is the Human Being?" The Philosophy of Symbolic Forms is Cassirer's most important work. It was first published in German in 1923, the third and final volume appearing in 1929. In it Cassirer presents a radical new philosophical worldview - at once rich, creative and controversial - of human beings as fundamentally "symbolic animals," placing signs and systems of expression between themselves and the world. This major new translation of all three volumes, the first for over fifty years, brings Cassirer's magnum opus to a new generation of students and scholars. Taken together, the three volumes of The Philosophy of Symbolic Forms are a vital treatise on human beings as symbolic animals and a monumental expression of neo-Kantian thought. Correcting important errors in previous English editions, this translation reflects the contributions of significant advances in Cassirer scholarship over the last twenty to thirty years. Each volume includes a new introduction and translator's notes by S. G. Lofts, a foreword by Peter Gordon, a glossary of key terms, and a thorough index. (shrink)

BackgroundBiobanking biospecimens and consent are common practice in paediatric research. We need to explore children and young people’s (CYP) knowledge and perspectives around the use of and consent to biobanking. This will ensure meaningful informed consent can be obtained and improve current consent procedures.MethodsWe designed a survey, in co-production with CYP, collecting demographic data, views on biobanking, and consent using three scenarios: 1) prospective consent, 2) deferred consent, and 3) reconsent and assent at age of capacity. The survey was disseminated (...) via the Young Person’s Advisory Group North England (YPAGne) and participating CYP’s secondary schools. Data were analysed using a qualitative thematic approach by three independent reviewers (including CYP) to identify common themes. Data triangulation occurred independently by a fourth reviewer.ResultsOne hundred two CYP completed the survey. Most were between 16–18 years (63.7%, N = 65) and female (66.7%, N = 68). 72.3% had no prior knowledge of biobanking (N = 73).Acceptability of prospective consent for biobanking was high (91.2%, N = 93) with common themes: ‘altruism’, ‘potential benefits outweigh individual risk’, 'frugality', and ‘(in)convenience’.Deferred consent was also deemed acceptable in the large majority (84.3%, N = 86), with common themes: ‘altruism’, ‘body integrity’ and ‘sample frugality’. 76.5% preferred to reconsent when cognitively mature enough to give assent (N = 78), even if parental consent was previously in place. 79.2% wanted to be informed if their biobanked biospecimen is reused (N = 80).ConclusionProspective and deferred consent acceptability for biobanking is high among CYP in the UK. Altruism, frugality, body integrity, and privacy are the most important themes. Clear communication and justification are paramount to obtain consent. Any CYP with capacity should be part of the consenting procedure, if possible. (shrink)

Ernst Cassirer est un philosophe juif allemand, contemporain de la Seconde Guerre mondiale. Auteur majeur pour l'histoire de la pensée occidentale, il est cependant resté dans l'ombre de Heidegger pendant de nombreuses années. Sa philosophie, centrée sur la question de la culture et du politique, trouve dans la forme symbolique du mythe une explication à la naissance du totalitarisme. Dans une démarche critique, Cassirer analyse l'apparition du mythe totalitaire en Allemagne comme une crise culturelle ayant engendré par la suite (...) une crise morale et politique. Cette crise culturelle trouve sa source au sein du courant romantique allemand, dont les mauvaises interprétations – ou réutilisations – par les idéologues nazis ont conduit aux dérives nationalistes et au culte du héros. À la pensée mythique, Cassirer oppose la pensée libre, éclairée et critique, seule voie de sortie possible selon lui pour dépasser le mythe totalitaire. « Sapere aude! », selon la formule kantienne : osons penser! Ayons le courage de nous servir de notre propre entendement. (shrink)

Normal 0 21 In 1802 Hegel publishes in Jena “On the Relationship of Skepticism to Philosophy”. This article has the objective of criticizing the skepticism of Gottlob Ernst Schulze. The accomplishment of that critic will demand from Hegel the review of some fundamental aspects of the ancient skepticism. It treats here of reconsidering Hegel’s interpretation of the ancient skepticism, starting from that critic to the modern skepticism of Schulze.

The present analysis of the evolution of the concept of freedom in Ernst Tugendhat’s philosophy aims to highlight several interesting facts. First, Tugendhat attempts to describe the meaning of Kant’s statement “I could have acted otherwise” from a non-transcendental perspective. Second, he makes an effort to avoid the classical Kantian dilemma of the relation of free will and determinism by posing the question differently. Third, he situates the issue of the relation of freedom and causality in the framework of (...) the inner structure of freedom – examining it from the perspective of the human’s relation to him- or herself. Fourth, he attempts repeatedly to overcome the impossibility of considering freedom in the objective language of causality. The paper demonstrates why the issue of freedom remains a central problem of continental philosophy. (shrink)

Eu creio que devemos agradecer a Heidegger por nos ter claramente colocado, diante de nossos olhos, o verdadeiro “acontecimento” filosófico, que se consuma na fundamentação da filosofia de Kant, de modo que tal acontecimento torna-se visível na totalidade de sua força interna e em seu ímpeto. Mas, me parece que ele não percorreu a totalidade da esfera da problemática do “idealismo transcendental”.

Article Punt, Jozef: Die Idee der Menschenrechte. Ihre geschichtliche Entwicklung und ihre Rezeption durch die moderne katholische Sozialverkündigung Böckenförde, Ernst, Wolfgang und Spaemann, Robert (Hg.): Menschenrechte und Menschenwürde. Historische Voraussetzungen - säkulare Gestalt - christliches Verständnis was published on February 1, 1989 in the journal Zeitschrift für Evangelische Ethik (volume 33, issue 1).

Contents: K. Ludeking, The Body and the Letters Albrecht Durer s self-portrait from 1500; E. Osterkamp, Spartacus under the Germans on the history of a literary legacy; F. Forster-Hahn, German, Modern and Jewish Max Liebermann s 1906 exhibitions in Berlin and London; U. Haselstein, A Genealogy of Modernity Flaubert, Cezanne, and Gertrude Stein; C. Asendurf, Bodies in Force Fields Art War and Spatial Theory in Classical Modernity.".

--Prophet mit Marx- und Engelszungen, von M. Walser.--Philosophie zwischen Traum und Apokalypse, von I. Frenzel.--Messianismus und Marxismus, von J. Moltmann.--Ein marxistischer Schelling, von J. Habermas.--Ein Gespräch über ungelöste Aufgaben der sozialistischen Theorie, von E. Bloch und F. Vilmar.--Ein grosser Einzelgänger, von I. Fetscher.--Ernst Blochs Evolution des Marxismus, von W. Maihofer.--Ausgewählte Bibliographie der Schriften über Ernst Bloch, zusammengestellt von R. Kübler (p. 133-[149]).

Growing interest has been shown toward humanism in the 21st century after decades of critique and rejection. Posthumanism and transhumanism have redefined the topic primarily through developments in technology and by focusing on relations of interconnectedness between humans and the environment. A different concern with ‘being human’ can be found in the writings of Zygmunt Bauman and Ernst Bloch. The leitmotif of Bauman’s sociology and of Bloch’s utopian philosophy is their assertion that humans have the distinct capacity to transcend (...) necessity and inevitability. Their works share the concern for a good society that would ameliorate social fragmentation and disintegration. Following this, the article seeks to theorize the meaning of humanism in the contemporary era. Taking up Bauman’s notion of interregnum, the article will argue that the contemporary importance of humanism is social in the sense of redeeming the currently casualized human condition, i.e. diminished life-chances, inequality and alienation. Interregnum marks a historical epoch where the old order has decayed, but the new one is not yet present. In interregnum, or in what Bloch calls Mischzeit, humanism is about a human being-in-the-world which contains the possibility to do better. (shrink)

This chapter contains section titled: Discussion.

Richard Rorty wird einleitend als zugleich bekanntester und umstrittenster Neopragmatist vorgestellt. Diese Einführung bietet dann den NutzerInnen des Handbuchs eine erste Übersicht über Rortys Version des Pragmatismus. Sie betont dabei seinen demokratischen Antiautoritarismus, dessen transformativer Anspruch ernst genommen werden muss. Anschließend werden die wichtigsten Themen der Rorty-Forschung übersichtlich strukturiert: Die Debatten kreisen um diesen Anspruch und um die (zu rigiden) Schlüsselunterscheidungen seines Denkens: Argumentation/Neubeschreibung, Kausalität/Rechtfertigung, privat/öffentlich. Das Hauptziel des Handbuchs besteht darin, einen systematischen und umfassenden Überblick über Rortys Denken (...) zu geben. Darüber hinaus will es das Forschungsgespräch zu Rorty fortführen. Die Ausführungen über diese Ziele des Handbuchs leiten über auf einen Überblick über den daraus resultierenden Aufbau und die einzelnen Teile des Bandes. Eine Schlussbemerkung und die Danksagungen beschließen diese Einführung. (shrink)